| 23 | 0 | 14 |
| 下载次数 | 被引频次 | 阅读次数 |
目的 分析2011—2025年河南省平顶山市梅毒流行特征及时空聚集性，为本地区梅毒防控策略制定提供流行病学依据。方法 收集2011—2025年平顶山市梅毒网络报告病例资料，采用描述性流行病学方法分析病例时间、地区、人群及疾病分期分布；采用Joinpoint回归模型分析报告发病率时序变化趋势；采用空间自相关分析及时空扫描统计分析识别发病空间聚集特征。结果 2011—2025年平顶山市累计报告梅毒病例12 948例，年均报告发病率为21.58/10万。报告发病率总体呈先升后降再升的阶段性波动变化。病例以隐性梅毒为主，占75.86%；≥20岁年龄组均以隐性梅毒为主，且占比随年龄增加而升高。不同地区发病率存在差异，高发地区主要为舞钢市、叶县和石龙区。空间分析显示，在未校正检验水准下，2016年和2019年呈弱正向全局空间自相关，经多重比较校正后，各年份全局空间自相关均无统计学意义；局部空间自相关和时空扫描识别出多个高风险聚集区。结论 平顶山市梅毒疫情总体呈先升后降再升趋势。隐性梅毒为主要报告类型。病例主要集中于≥60岁人群、20～39岁女性及农民、家务和待业人群，部分地区存在时空聚集。应加强隐性梅毒早期筛查、重点人群干预和高风险地区精准防控。
Abstract：Objective To analyze the epidemiological characteristics and spatiotemporal clustering of syphilis in Pingdingshan, Henan Province, from 2011 to 2025, and to provide evidence for syphilis prevention and control. Methods Data on reported syphilis cases in Pingdingshan from 2011 to 2025 were collected. Descriptive epidemiological methods were used to analyze the distribution of cases by time, region, population characteristics, and disease stage. Joinpoint regression was used to analyze trends in reported incidence. Spatial autocorrelation analysis and spatiotemporal scan statistics were used to identify spatial clustering patterns. Results A total of 12,948 syphilis cases were reported in Pingdingshan from 2011 to 2025, with an average annual reported incidence of 21.58 per 100,000 population. The reported incidence showed a phased pattern of initial increase, subsequent decline, and later increase. Latent syphilis was the predominant stage, accounting for 75.86% of all reported cases. Among individuals aged 20 years and above, latent syphilis was the main reported stage, and its proportion increased with age. Reported incidence varied across regions, with higher incidence mainly observed in Wugang City, Ye County, and Shilong District. Spatial analysis showed weak positive global spatial autocorrelation in 2016 and 2019 at the nominal significance level; however, global spatial autocorrelation was no longer statistically significant in any year after multiple comparison correction. Local spatial autocorrelation and spatiotemporal scan analysis identified several high-risk clusters. Conclusion The syphilis epidemic in Pingdingshan City generally showed a trend of rising, then falling, and then rising again. Latent syphilis was the predominant reported stage. Cases were mainly concentrated among people aged ≥60 years, women aged 20–39 years, and farmers, homemakers, and unemployed individuals. Spatiotemporal clustering was observed in some areas. Efforts should be strengthened to promote earlier detection of latent syphilis, targeted screening of key populations, and precise prevention and control in high-risk areas.
[1]张奕南，袁嫣仪，何伟清，等. 2015—2024年广东省中山市梅毒流行趋势分析：基于Joinpoint回归模型[J].皮肤性病诊疗学杂志，2025,32(12):878-885. DOI:10.3969/j.issn.1674-8468.2025.12.006.
[2]张向怡. 2004—2018年中国潜伏梅毒空间聚集性特征分析[D].长春：吉林大学，2022. DOI:10.27162/d.cnki.gjlin.2022.001354.
[3]陈泽伟，梁诗晴，岳晓丽，等. 2010—2023年中国梅毒流行趋势及时空分布特征[J].中华皮肤科杂志，2024,57(11):1045-1050. DOI:10.35541/cjd.20240073
[4]中国疾病预防控制中心性病艾滋病预防控制中心. 2025年12月全国艾滋病性病疫情[J].中国艾滋病性病，2026,32(3):253. DOI:10.13419/j.cnki.aids.2026.03.01.
[5]石朝辉，闫江舟，孙秀丽，等. 2019—2021年平顶山市性病门诊男性就诊者艾滋病哨点监测结果分析[J].华南预防医学，2023,49(1):101-104. DOI:10.12183/j.scjpm.2023.0101.
[6]朱斌，刘锦林，毛瑛.中国典型法定报告传染病发病率空间关联性分析[J].中国公共卫生，2018,34(1):4-8. DOI:10.11847/zgggws1114291.
[7]卢晓丽，张春阳，柯丽贞，等.福建省2010—2022年梅毒时空分布特征研究[J].中国艾滋病性病，2023,29(11):1245-1249. DOI:10.13419/j.cnki.aids.2023.11.16.
[8]张小荣，栾荣生.中国梅毒防控规划实施后对梅毒发病的影响[J].现代预防医学，2023,50(7):1321-1326. DOI:10.20043/j.cnki.MPM.202210227.
[9]中华人民共和国卫生部办公厅.关于印发《预防艾滋病、梅毒和乙肝母婴传播工作实施方案》的通知[EB/OL].(2011-02-28)[2026-04-15]. https://www.nhc.gov.cn/wjw/gfxwj/201102/aa934f-3c8e18467fb718c610da723312.shtml.
[10]中华人民共和国卫生部.卫生部关于印发《中国预防与控制梅毒规划（2010—2020年）》的通知：卫疾控发[2010]52号[EB/OL].(2010-06-21)[2026-08-06]. https://www.nhc.gov.cn/zwgk/wtwj/201304/bb67c7a0e7c140d7b5ad25ca5106b659.shtml.
[11]吴月琳，朱文倩，岳晓丽，等.新型冠状病毒肺炎流行对我国梅毒病例报告结果的影响[J].中华流行病学杂志，2022,43(12):2015-2020. DOI:10.3760/cma.j.cn112338-20220920-00794
[12]Wu X, Zhou X, Chen Y, et al. The impact of COVID-19 lockdown on cases of and deaths from AIDS, gonorrhea, syphilis, hepatitis B, and hepatitis C:interrupted time series analysis[J]. JMIR Public Health Surveill, 2023, 9:e40591. DOI:10.2196/40591.
[13]Centers for Disease Control and Prevention. Impact of COVID-19on STIs[EB/OL].(2024-11-12)[2026-05-10]. https://www.cdc.gov/sti-statistics/about/impact-of-covid-19.html.
[14]Thng C, Hughes I, Poulton G, et al. 18 months on:an interrupted time series analysis investigating the effect of COVID-19 on chlamydia and gonorrhoea testing and test positivity at the Gold Coast, Australia[J]. Sex Health, 2022, 19(2):127-131. DOI:10.1071/SH21231.
[15]Schwartz N, Hunter S, Forbes S M, et al. The COVID-19 pandemic's impact on sexually transmitted infections and the modifying role of public health funding:an interrupted time series study[J]. J Public Health(Oxf), 2025, 47(3):395-403. DOI:10.1093/pubmed/fdaf053.
[16]Cao G, Huang J, Cai J, et al. The changing epidemiology of syphilis:new strategies for new challenges in China[J]. Lancet Reg Health West Pac, 2025, 65:101752. DOI:10.1016/j.lanwpc.2025.101752.
[17]Qiao Y, Guo J, Cheng R, et al. Epidemiological characteristics of syphilis in China from 2005 to 2020:predominance of latent infections, significant burden in the elderly population, and analysis of regional disparities[J]. BMC Public Health, 2026, 26:147. DOI:10.1186/s12889-025-25513-y.
[18]游贵俊，赵立华. 2 0 1 3—2 0 2 2年宁夏梅毒流行特征[J].中国皮肤性病学杂志，2024,38(1):81-85. DOI:10.13735/j.cjdv.1001-7089.202307053.
[19]彭嘉俊，何婉苹，杨韵青，等. 2004—2023年广州市梅毒流行趋势分析：基于Joinpoint回归模型[J].皮肤性病诊疗学杂志，2025,32(5):345-350. DOI:10.3969/j.issn.1674-8468.2025.05.006
[20]张显明，刘绪英，李臻，等. 2018—2022年邹城市梅毒发病情况及流行病学特征分析[J].中国公共卫生管理，2024,40(1):134-136+145. DOI:10.19568/j.cnki.23-1318.2024.01.0034.
[21]秦永发，毕亚涛，赵佳，等. 2005—2020年中国胎传梅毒发病趋势分析及预测[J].公共卫生与预防医学，2026,37(2):12-16. DOI:10.3969/j.issn.1006-2483.2026.02.003
[22]陶金，章静，豆正东，等. 2015—2024年芜湖市梅毒流行特征及趋势分析[J].热带病与寄生虫学，2026,24(1):41-46. DOI:10.20199/j.issn.1672-2302.2026.01.008.
[23]张静航，高守芝，郑军，等.基于Joinpoint回归模型的2004—2022年湖南省梅毒流行趋势分析[J].中国艾滋病性病，2024,30(3):299-302. DOI:10.13419/j.cnki.aids.2024.03.14.
[24]许纯，李锦成，杨文彬，等. 2013—2023年扬州市梅毒流行病学特征分析[J].实用临床医药杂志，2024,28(21):22-27. DOI:10.7619/jcmp.20241868
[25]李芳芳，刘建华，张皓，等. 2011—2020年宜昌市梅毒流行病学特征分析[J].公共卫生与预防医学，2023,34(2):105-108. DOI:10.3969/j.issn.1006-2483.2023.02.023
[26]平顶山市统计局，国家统计局平顶山调查队.平顶山统计年鉴2025[M].平顶山：平顶山市统计局，2025.
[27]田婷婷，侯雅宣，李雨晴，等.中国梅毒发病率的时空分布特征分析[J].上海交通大学学报（医学版），2021,41(5):648-652. DOI:10.3969/j.issn.1674-8115.2021.05.015
[28]李巧梅，赵虹琳，张亚南，等. 2004—2019年中国大陆地区梅毒空间聚集性分析[J].中国预防医学杂志，2021,22(12):952-955. DOI:10.16506/j.1009-6639.2021.12.011.
[29]Tang S, Shi L, Chen W, et al. Spatiotemporal distribution and sociodemographic and socioeconomic factors associated with primary and secondary syphilis in Guangdong, China, 2005–2017[J]. PLoS Negl Trop Dis, 2021, 15(8):e0009621. DOI:10.1371/journal.pntd.0009621.
[30]Wong N S, Huang S, Zheng H, et al. Stages of syphilis in South China:a multilevel analysis of early diagnosis[J]. BMC Public Health,2017, 17:135. DOI:10.1186/s12889-016-4004-y.
[31]中国疾病预防控制中心性病控制中心，中华医学会皮肤性病学分会性病学组，中国医师协会皮肤科医师分会性病亚专业委员会.梅毒、淋病和生殖道沙眼衣原体感染诊疗指南（2020年）[J].中华皮肤科杂志，2020,53(3):168-179. DOI:10.35541/cjd.20190808
基本信息:
中图分类号:R759.1;R181.3
引用信息:
[1]李琼,马西平,张国昌.2011—2025年河南省平顶山市梅毒流行特征及时空聚集性分析[J].传染病信息,2026,39(04):435-444.
2026-08-30
2026-08-30