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目的 分析厦门地区男性人乳头瘤病毒（human papillomavirus, HPV）感染现状，探索影响其发生的危险因素。方法 选取2024年4月至2024年5月在厦门大学附属翔安医院和厦门大学公共卫生学院招募的383例男性HPV采集志愿者，每个志愿者均采集阴茎龟头、阴囊、肛周、肛门4个部位标本并送检进行核酸检测。使用单因素和多因素Logistic回归分析影响男性HPV感染的危险因素，以单因素Logistics回归危险因素为基础，使用rms程序包将危险因素整合到列线图模型中，使用受试者工作曲线对验证集数据进行内部验证。结果 入组的383例男性志愿者中，经过数据清洗和筛选，最终361例志愿者纳入研究。本次研究中男性HPV感染总阳性率为23.2%，阴茎龟头感染阳性率为15.8%，阴囊感染阳性率为11.1%，会阴肛门感染阳性率为9.2%，肛门内感染阳性率为6.1%。高龄、长时间大量吸烟及饮酒、已婚、高频率的性生活和较少使用避孕套是影响男性HPV感染的危险因素（P均<0.05）。结论 随着采样的位置远离阴茎龟头，男性HPV检出率逐渐下降，过度的性生活和长时间大量吸烟及饮酒是引起HPV感染的重要危险因素。
Abstract：Objective To analyze the current status of human papillomavirus(HPV) infection among males in Xiamen and explore the risk factors influencing its occurrence. Methods A total of 383 male HPV sampling volunteers were recruited from Xiang'an Hospital Affiliated to Xiamen University and the School of Public Health at Xiamen University between April 2024 and May 2024. Specimens were collected from four anatomical sites(glans penis, scrotum, perianal region, and anal canal) for each volunteer and sent for nucleic acid testing. Univariate and multivariate logistic regression analyses were performed to identify risk factors for male HPV infection. Based on the univariate logistic regression results, the rms package(Regression Modeling Strategies) was used to integrate risk factors into a nomogram model. Internal validation was conducted using receiver operating characteristic(ROC) curve analysis on the validation dataset. Results After data cleaning and screening, 361 out of the 383 enrolled male volunteers were included in the study. The overall HPV positivity rate was 23.2%, with site-specific rates of 15.8%(glans penis), 11.1%(scrotum), 9.2%(perianal region), and 6.1%(anal canal). Advanced age, heavy and prolonged smoking and alcohol consumption, marital status, High-frequency sexual activity and infrequent condom use were identified as significant risk factors for male HPV infection(P<0.05). Conclusion The detection rate of HPV in males progressively decreases with increasing distance from the glans penis. Excessive sexual activity and prolonged heavy smoking and alcohol consumption are major risk factors.
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基本信息:
中图分类号:R759;R181.3
引用信息:
[1]王明山,杨毅,唐慧敏,等.厦门地区男性人乳头瘤病毒感染流行病学特点以及危险因素分析[J].传染病信息,2025,38(05):435-441+446.
基金信息:
国家自然科学基金资助项目(82472738); 福建省厦门市卫生高质量发展科技计划项目(2024GZL-QN017)
2025-10-30
2025-10-30