传染病信息

[1]王时佳，张宇丝，马樱，等.低密度中性粒细胞在病毒感染性疾病中的作用与机制研究进展[J].传染病信息，2025,38(1):93-97.DOI:10.3969/j.issn.1007-8134.2025.01.018.

[2]Huang S, Wang Y, Lin S, et al. Neutrophil autophagy induced by monosodium urate crystals facilitates neutrophil extracellular traps formation and inflammation remission in gouty arthritis[J]. Front Endocrinol(Lausanne), 2023, 14:1071630. DOI:10.3389/fendo.2023.1071630.

[3]Zhang YY, Wang JX, Qiao F, et al. Pparα activation stimulates autophagic flux through lipid catabolism-independent route[J]. Fish Physiol Biochem, 2024, 50(3):1141-1155. DOI:10.1007/s10695-024-01327-4.

[4]Jiang J, Tu H, Li P. Lipid metabolism and neutrophil function[J]. Cell Immunol, 2022, 377:104546. DOI:10.1016/j.cellimm.2022.104546.

[5]Morán G, Uberti B, Quiroga J. Role of cellular metabolism in the formation of neutrophil extracellular traps in airway diseases[J]. Front Immunol, 2022, 13:850416. DOI:10.3389/fimmu.2022.850416.

[6]Dai P, Tang Z, Qi M, et al. Dispersion and utilization of lipid droplets mediates respiratory syncytial virus-induced airway hyperresponsiveness[J]. Pediatr Allergy Immunol, 2022, 33(1):e13651. DOI:10.1111/pai.13651.

[7]Dahlgren C, Forsman H, Sundqvist M, et al. Signaling by neutrophil G protein-coupled receptors that regulate the release of superoxide anions[J]. J Leukoc Biol, 2024, 116(6):1334-1351. DOI:10.1093/jleuko/qiae165.

[8]Elimam H, Gauvin J, Huynh DN, et al. Targeting CD36 with EP 80317 reduces remote inflammatory response to hind limb ischemia-reperfusion in mice[J]. J Biochem Mol Toxicol, 2024,38(12):e70057. DOI:10.1002/jbt.70057.

[9]Jones BA, Myakala K, Guha M, et al. Farnesoid X receptor prevents neutrophil extracellular traps via reduced sphingosine-1-phosphate in chronic kidney disease[J]. Am J Physiol Renal Physiol, 2023,325(6):F792-F810. DOI:10.1152/ajprenal.00292.2023.

[10]Pham L, Komalavilas P, Eddie AM, et al. Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation[J].Commun Biol, 2022, 5(1):1366. DOI:10.1038/s42003-022-04339-z.

[11]Shi B, Chen J, Guo H, et al. ACOX1 activates autophagy via the ROS/mTOR pathway to suppress proliferation and migration of colorectal cancer[J]. Sci Rep, 2025, 15(1):2992. DOI:10.1038/s41598-025-87728-8.

[12]Kumar S, Dikshit M. Metabolic insight of neutrophils in health and disease[J]. Front Immunol, 2019, 10:2099. DOI:10.3389/fimmu.2019.02099.

[13]Lodhi IJ, Semenkovich CF. Peroxisomes:a nexus for lipid metabolism and cellular signaling[J]. Cell Metab, 2014, 19(3):380-392. DOI:10.1016/j.cmet.2014.01.002.

[14]Lavoie SS, Dumas E, Vulesevic B, et al. Synthesis of human neutrophil extracellular traps contributes to angiopoietin-mediated in vitro proinflammatory and proangiogenic activities[J]. J Immunol, 2018,200(11):3801-3813. DOI:10.4049/jimmunol.1701203.

[15]Xuan W, Wu X, Zheng L, et al. Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4[J]. Cell Mol Life Sci,2024, 81(1):438. DOI:10.1007/s00018-024-05474-y.

[16]Leblanc PO, Bourgoin SG, Poubelle PE, et al. Metabolic regulation of neutrophil functions in homeostasis and diseases[J]. J Leukoc Biol,2024, 116(3):456-468. DOI:10.1093/jleuko/qiae025.

[17]Huang S, Shi J, Shen J, et al. Metabolic reprogramming of neutrophils in the tumor microenvironment:Emerging therapeutic targets[J]. Cancer Lett, 2025, 612:217466. DOI:10.1016/j.canlet.2025.217466.

[18]Sankar P, Ramos RB, Corro J, et al. Fatty acid metabolism in neutrophils promotes lung damage and bacterial replication during tuberculosis[J]. PLoS Pathog, 2024, 20(10):e1012188. DOI:10.1371/journal.ppat.1012188.

[19]Yalcinkaya M, Fotakis P, Liu W, et al. Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion[J]. Cardiovasc Res, 2023, 119(4):969-981. DOI:10.1093/cvr/cvac189.

[20]Al-Kuraishy HM, Hussien NR, Al-Niemi MS, et al. SARS-CoV-2induced HDL dysfunction may affect the host's response to and recovery from COVID-19[J]. Immun Inflamm Dis, 2023, 11(5):e861. DOI:10.1002/iid3.861.

[21]Wang Y, Zhang J, Li H, et al. Prognostic value of leucocyte to high-density lipoprotein-cholesterol ratios in COVID-19 patients and the diabetes subgroup[J]. Front Endocrinol(Lausanne), 2021,12:727419. DOI:10.3389/fendo.2021.727419.

[22]Mohammadshahi J, Ghobadi H, Matinfar G, et al. Role of lipid profile and its relative ratios(cholesterol/HDL-C, triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C)on admission predicts in-hospital mortality COVID-19[J]. J Lipids, 2023,2023:6329873. DOI:10.1155/2023/6329873.

[23]Memiç-İnan C,Çapraz M,Çapraz A. Association of blood lipids with mortality in COVID-19 patients[J]. Lipids, 2025, 60(4):229-235.DOI:10.1002/lipd.12437.

[24]Wang N, Zheng Y, Tao S, et al. Lipid metabolism disturbance and immune dysfunction in HBV-related acute-on-chronic liver failure:a retrospective cohort study[J]. BMC Gastroenterol, 2025, 25(1):444.DOI:10.1186/s12876-025-04004-9.

[25]单悦，徐剑媛，邱源旺.乙型肝炎病毒与肝脂质代谢相关性的研究进展[J].传染病信息，2023,36(2):178-182. DOI:10.3969/j.issn.1007-8134.2023.02.017.

[26]Yan Q, Jia S, Li D, et al. The role and mechanism of action of microbiota-derived short-chain fatty acids in neutrophils:From the activation to becoming potential biomarkers[J]. Biomed Pharmacother,2023, 169:115821. DOI:10.1016/j.biopha.2023.115821.

[27]Chen PH, Lee TW, Liu SH, et al. Lithium downregulates phosphorylated acetylCoA carboxylase 2 and attenuates mitochondrial fatty acid utilization and oxidative stress in cardiomyocytes[J]. Exp Ther Med,2024, 27(4):126. DOI:10.3892/etm.2024.12413.

[28]Thomas T, Stefanoni D, Reisz JA, et al. COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status[J]. JCI Insight, 2020,5(14):140327. DOI:10.1172/jci.insight.140327.

[29]Palanki R, Yamagata H, Mitchell MJ. OLAH connects fatty acid metabolism to the severity of respiratory viral disease[J]. Cell, 2024,187(17):4549-4551. DOI:10.1016/j.cell.2024.07.032.

[30]李艳梅，魏云林，李海燕，等.病毒感染影响宿主细胞代谢研究进展[J].生物工程学报，2023,39(9):3566-3578. DOI:10.13345/j.cjb.220888.

[31]Syed GH, Amako Y, Siddiqui A. Hepatitis C virus hijacks host lipid metabolism[J]. Trends Endocrinol Metab, 2010, 21(1):33-40. DOI:10.1016/j.tem.2009.07.005.

[32]Bu L, Wang H, Zhang S, et al. Targeting APT2 improves MAVS palmitoylation and antiviral innate immunity[J]. Mol Cell, 2024,84(18):3513-3529.e5. DOI:10.1016/j.molcel.2024.08.014.

[33]Khoi CS, Lin TY, Chiang CK. Targeting insulin resistance, reactive oxygen species, inflammation, programmed cell death, ER stress, and mitochondrial dysfunction for the therapeutic prevention of free fatty acid-induced vascular endothelial lipotoxicity[J]. Antioxidants(Basel), 2024, 13(12):1486. DOI:10.3390/antiox13121486.

[34]Li Y, Zhang Y, Deng Q, et al. Resveratrol reverses palmitic acid-induced cow neutrophils apoptosis through shifting glucose metabolism into lipid metabolism via Cav-1/CPT 1-mediated FAO enhancement[J]. J Steroid Biochem Mol Biol, 2023, 233:106363. DOI:10.1016/j.jsbmb.2023.106363.

[35]Chollet L, Heumel S, Deruyter L, et al. Faecalibacterium duncaniae as a novel next generation probiotic against influenza[J]. Front Immunol,2024, 15:1347676. DOI:10.3389/fimmu.2024.1347676.

[36]Das S, Raundhal M, Chen J, et al. Respiratory syncytial virus infection of newborn CX3CR1-deficient mice induces a pathogenic pulmonary innate immune response[J]. JCI Insight, 2017, 2(17):e94605.DOI:10.1172/jci.insight.94605.

[37]赵天伦，秦露，刘亚丽，等.呼吸道合胞病毒感染与脂质代谢相关性研究进展[J].病毒学报，2023,39(6):1713-1719. DOI:10.13242/j.cnki.bingduxuebao.004384.

[38]Pham L, Komalavilas P, Eddie AM, et al. Neutrophil trafficking to the site of infection requires Cpt1a-dependent fatty acid β-oxidation[J].Commun Biol, 2022, 5(1):1366. DOI:10.1038/s42003-022-04339-z.

[39]Veras FP, Pontelli MC, Silva CM, et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology[J]. J Exp Med, 2020, 217(12):e20201129. DOI:10.1084/jem.20201129.

[40]Youn YJ, Lee YB, Kim SH, et al. Nucleocapsid and spike proteins of SARS-CoV-2 drive neutrophil extracellular trap formation[J]. Immune Netw, 2021, 21(2):e16. DOI:10.4110/in.2021.21.e16.

[41]De la Cruz-Enríquez J, Rojas-Morales E, Ruíz-García MG, et al.SARS-CoV-2 induces mitochondrial dysfunction and cell death by oxidative stress/inflammation in leukocytes of COVID-19 patients[J]. Free Radic Res, 2021, 55(9-10):982-995. DOI:10.1080/10715762.2021.2005247.

[42]Hsieh LL, Thompson EA, Jairam NP, et al. SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19[J]. Sci Transl Med,2025, 17(799):eadn7527. DOI:10.1126/scitranslmed.adn7527.

[43]Hosseini A, Stojkov D, Fettrelet T, et al. Transcriptional insights of oxidative stress and extracellular taps in lung tissues of fatal COVID-19 cases[J]. Int J Mol Sci, 2023, 24(3):2646. DOI:10.3390/ijms24032646.

[44]Hsieh LL, Thompson EA, Jairam NP, et al. SARS-CoV-2 induces neutrophil degranulation and differentiation into myeloid-derived suppressor cells associated with severe COVID-19[J]. Sci Transl Med,2025, 17(799):eadn7527. DOI:10.1126/scitranslmed.adn7527.

[45]Gosselin J, Savard M, Tardif M, et al. Epstein-Barr virus primes human polymorphonuclear leucocytes for the biosynthesis of leukotriene B4[J]. Clin Exp Immunol, 2001, 126(3):494-502. DOI:10.1046/j.1365-2249.2001.01687.x.

[46]Hawryłkowicz V, Stasiewicz B, Maciejewska D, et al. The link between inflammation, lipid derivatives, and microbiota metabolites in COVID-19 patients:Implications on eating behaviors and nutritional status[J]. Int J Mol Sci, 2024, 25(14):7899. DOI:10.3390/ijms25147899.

[47]Mosso-Pani MA, Barreda D, Salazar MI. Dynamic regulation of neutrophil immunometabolism by platelet-derived metabolites[J]. Front Immunol, 2025, 16:1542438. DOI:10.3389/fimmu.2025.1542438.

[48]Rodriguez NR, Fortune T, Hegde E, et al. Oxidative phosphorylation in HIV-1 infection:impacts on cellular metabolism and immune function[J]. Front Immunol, 2024, 15:1360342. DOI:10.3389/fimmu.2024.1360342.

[49]Jarstrand C, Akerlund B. Oxygen radical release by neutrophils of HIV-infected patients[J]. Chem Biol Interact, 1994, 91(2-3):141-146.DOI:10.1016/0009-2797(94)90034-5.

[50]Piatek P, Tarkowski M, Namiecinska M, et al. H3K4me3 histone ChIP-seq analysis reveals molecular mechanisms responsible for neutrophil dysfunction in HIV-infected individuals[J]. Front Immunol,2021, 12:682094. DOI:10.3389/fimmu.2021.682094.

[51]Dunsmore G, Rosero EP, Shahbaz S, et al. Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9from the cell surface during HIV infection[J]. PLoS Biol, 2021,19(8):e3001387. DOI:10.1371/journal.pbio.3001387.

[52]苏比奴尔·阿不都克力木，秦旭阳，陆蕾，等.艾滋病肾损伤进展中的能量代谢重编程[J].传染病信息，2024,37(6):555-560.DOI:10.3969/j.issn.1007-8134.2024.06.0016.