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2025, 03, v.38 301-306
B7家族分子在病毒感染中的作用研究进展
基金项目(Foundation): 陕西省重点研发计划项目(2023-ZDLSF-32)
邮箱(Email): zyfmmu@hotmail.com;
DOI:
摘要:

病毒感染过程中多伴有机体免疫功能紊乱,造成免疫病理损伤或免疫耐受,制约机体清除病原体,加重组织损伤。机体特异性免疫反应的激活不仅需要主要组织相容性复合物(major histocompatibility complex, MHC)分子呈递处理过的抗原,还需要共刺激分子作为“第二信号”发挥调节作用。B7家族是一类重要的共刺激分子,它们可以与淋巴细胞表面受体结合,与抗原肽-MHC复合物共同作用,进而激活或抑制适应性免疫反应。本文总结了近年来国内外对于B7家族共刺激分子在病毒感染中作用的研究进展,以期为深入研究B7家族分子功能及进一步转化应用提供新思路。

Abstract:

Viral infections are often accompanied by immune dysfunction, resulting in either hyperimmunity or immune tolerance, triggering series of pathological damages. The initiation of adaptive immune response requires not only MHC molecules to present processed antigens but also a class of co-stimulatory molecules serve as a "second signal". The B7 family is a group of co-stimulatory molecules that can bind to lymphocyte surface receptors and determine the activation or inhibition of immune response. These moleculesare crucial for immune regulation. This review summarizes the recent research progress on the role of B7family co-stimulatory molecules in viral infections, aiming to provide insights for future mechanism and application research.

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基本信息:

DOI:

中图分类号:R511

引用信息:

[1]李怡,郑煦暘,张颖.B7家族分子在病毒感染中的作用研究进展[J].传染病信息,2025,38(03):301-306.

基金信息:

陕西省重点研发计划项目(2023-ZDLSF-32)

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